… as of rats with type 2 diabetes induced by streptozotocin via a mechanism that may involve excessive activation of the poly (ADP ribose) polymerase-1/P53 pathway

J Xiang, XL Qi, K Cao, LY Ran, XX Zeng, X Xiao… - Science of The Total …, 2024 - Elsevier
… - or high-dose fluoride, and P53-knockdown or poly-ADP-ribose polymerase-1 (PARP-1)
inhibition. The levels of PARP-1, P53, poly-ADP-ribose (PAR), apoptosis-inducing factor (AIF), …

Propolis ethanol extract abrogates hyperglycemia, lipotoxicity, and lowered hepatic poly (ADP-ribose) polymerase protein level in male albino rats

RN Ugbaja, TP Fatokun, DI Akinloye, AS James… - … & Metabolic Disorders, 2021 - Springer
dysfunction which contributes to atherosclerosis. Atherosclerosis and dyslipidemia are major
risk factors for cardio-cerebrovascular … 21, 34], suggesting diabetes-induced organ damage. …

Role of ketone bodies in diabetes-induced dementia: sirtuins, insulin resistance, synaptic plasticity, mitochondrial dysfunction, and neurotransmitter

JY Chung, OY Kim, J Song - Nutrition reviews, 2022 - academic.oup.com
… 84 , 85 caused by fasting, and activates mitochondrial function, and inhibits the activation
of poly[ADP-ribose] polymerase 1 as a DNA damage index 86 , 87 caused by fasting (Figure …

Hyperbaric oxygen therapy dampens inflammatory cytokine production and does not worsen the cardiac function and oxidative state of diabetic rats

R Benkő, Z Miklós, VA Ágoston, K Ihonvien, C Répás… - Antioxidants, 2019 - mdpi.com
Poly(ADP-ribose) polymerase (PARP) activity was estimated in cardiac and aortic tissue.
HBOT did not alter most of the cardiovascular parameters. PARylation in cardiac and aortic …

Bidirectional regulation role of PARP-1 in high glucose-induced endothelial injury

Y Zhang, W Wang - Experimental Cell Research, 2022 - Elsevier
Loss of poly (ADP-ribose) polymerase-1 (PARP-1) has been found to slow the progression
of diabetes and diabetic angiopathy. In our study, we found bidirectional regulation of PARP-…

Mitigating effect of biotin against irradiation-induced cerebral cortical and hippocampal damage in the rat brain tissue

N Abdel-Magied, SM Shedid, AG Ahmed - Environmental science and …, 2019 - Springer
… technique using rat poly-ADP-ribose polymerase (MBS9426311) from MyBioSource.com. …
effect on the cerebral cortex of irradiated rats, while it revealed a pivotal role in mitigating the …

Pleiotropic role of PARP1: an overview

V Kumar, A Kumar, KUI Mir, V Yadav, SS Chauhan - 3 Biotech, 2022 - Springer
… one molecule of ADP-ribose residue or poly ADP-ribose units (… Poly (ADP-ribose) (PAR)
synthesis and its autoparylation. The PARs attached to PARP1 are released by poly (ADP-ribose

Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach

R Akram, H Anwar, MS Javed, A Imran… - … Journal of Food …, 2023 - Taylor & Francis
… : Poly ADP-ribose polymerase (PARP) pathway get activated due to higher level of oxidative
stress and eventually result in neuronal dysfunction… and diabetes-induced neuronal damage …

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

SS Hammer, CP Vieira, D McFarland, M Sandler… - Diabetologia, 2021 - Springer
diabetes-induced vascular and mitochondrial damage by inhibiting NF-κB [8], poly [ADP-ribose]
polymerase (PARP… Importantly, diabetes-induced decreases in SIRT1 signalling result in …

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

M Knapp, X Tu, R Wu - Acta Pharmacologica Sinica, 2019 - nature.com
… evidence regarding how diabetes-induced endothelial dysfunction mediates cardiac dysfunction.
… Its activation stimulates the transfer of ADP-ribose units from NAD + to nuclear proteins, …